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Recombinant Rat VEGF



Catalog Number : 400-31

Description

VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothellial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase(flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant rat VEGF is a 38.5 kDa disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Human
 
Biological Activity
Determined by the dose-dependent stimulation of the proliferation of Human umbilical vein endothelial cells (HUVEC). The expected ED50 is 4.0-8.0 ng/ml.
 
AA Sequence
MAPTTEGEQ KAHEVVKFM DVYQRSYCR PIETLVDIF QEYPDEIEY IFKPSCVPL MRCAGCCND EALECVPTS ESNVTMQIM RIKPHQSQH IGEMSFLQH SRCECRPKK DRTKPEKHC EPCSERRKH LFVQDPQTC KCSCKNTDS RCKARQLEL NERTCRCDK PRR
Research Interest: Stem Cell Research, Cancer, Angiogenesis, Inflammation, Proliferation and Cell Cycle
Cell Type: Monocytes and Macrophages, Stem Cells
Protein Cross Reactivity: Human

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$780.00
500µg
$2,340.00
1mg
$3,900.00