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Recombinant Rat Oncostatin M



Catalog Number : 400-36

Description

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi’s sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. Recombinant rat Oncostatin M is a 24.4 kDa protein, containing 215 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Assay #1:Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 is 3.0-5.0 μg/ml.
Assay #2: Determined by its ability to inhibit Alkaline phosphata
 
AA Sequence
MKRGCSSSS PKLLSQLKS QANITGNTA SLLEPYILH QNLNTLTLR AACTEHPVA FPSEDMLRQ LSKPDFLST VHATLGRVW HQLGAFRQQ FPKIQDFPE LERARQNIQ GIRNNVYCM ARLLHPPLE IPEPTQADS GTSRPTTTA PGIFQIKID SCRFLWGYH RFMGSVGRV FEEWGDGSR RSRRHSPLW AWLKGDHRI RPSRSSQSA MLRSLVPR
Research Interest: Innate Immunity, Adaptive Immunity, Stem Cell Research, Angiogenesis, Bone Biology, Inflammation
Cell Type: Monocytes and Macrophages, T Cells, Dendritic Cells
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$1,040.00
500µg
$3,120.00
1mg
$5,200.00