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Recombinant Rat MIP-1α (CCL3)



Catalog Number : 400-15

Description

Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant rat MIP-1α is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Human
 
Biological Activity
Assay#1:  Determined by its ability to chemoattract rat peritoneal macrophages using a concentration of 50.0-100.0 ng/ml.

Assay#2:  Determined by its ability to chemoattract human blood monocytes us
 
AA Sequence
APYGADTPT ACCFSYGRQ IPRKFIADY FETSSLCSQ PGVIFLTKR NRQICADPK ETWVQEYIT ELELNA
Research Interest: Innate Immunity, Neurosciences, Inflammation
Cell Type: Monocytes and Macrophages, NK and NKT Cells
Protein Cross Reactivity: Human

Availability: In stock

Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00