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Recombinant Rat IL-4



Catalog Number : 400-04

Description

IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant rat IL-4 is a 14.0 kDa globular protein containing 126 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Mouse
 
Biological Activity
Tested by its ability to suppress LPS-induced TNF-α and MIP-2 production in mouse splenocytes.
 
AA Sequence
MHGCNDSPL REIINTLNQ VTEKGTPCT EMFVPDVLT ATRNTTENE LICRASRVL RKFYFPRDV PPCLKNKSG VLGELRKLC RGVSGLNSL RSCTVNEST LTTLKDFLE SLKSILRGK YLQSCTSMS
Research Interest: Innate Immunity, Adaptive Immunity, Stem Cell Research, Apoptosis, Immunology, Cancer, Inflammation, Proliferation and Cell Cycle
Cell Type: T Cells
Protein Cross Reactivity: Mouse

Availability: In stock

Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$650.00
500µg
$1,950.00
1mg
$3,250.00