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Recombinant Rat IL-3β



Catalog Number : 400-03

Description

IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant rat IL-3β is a 16.3 kDa globular protein containing 144 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Mouse
 
Biological Activity
The ED50 was determined by the dose-dependent stimulation of the proliferation of thymidine uptake by murine MC-9 cells is < 10 ng/ml, corresponding to a specific activity of >1.0 x 1
 
AA Sequence
MISDRGSDA HHLLRTLDC RTIALEILV KLPYPQVSG LNNSDDKAN LRNSTLRRV NLDEFLKSQ EEFDSQDTT DIKSKLQKL KCCIPAAAS DSVLPGVYN KDLDDFKKK LRFYVIHLK DLQPVSVSR PPQPTSSSD NFRPMTVEC
Research Interest: Innate Immunity, Adaptive Immunity, Stem Cell Research, Immunology, Cancer, Proliferation and Cell Cycle
Cell Type: Monocytes and Macrophages, T Cells
Protein Cross Reactivity: Mouse

Availability: In stock

Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00