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Recombinant Rat IL-13 (113 a.a.)



Catalog Number : 400-16L

Description

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Recombinant rat IL-13 is a 12.3 kDa protein consisting of 113 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Human
 
Biological Activity
The ED50 was determined by the dose-dependent proliferation of TF-1 cells is < 5.0 ng/ml, corresponding to a specific activity of > 2 x 105 units/mg.
 
AA Sequence
TPGPVRRST SPPVALREL IEELSNITQ DQKTSLCNS SIVWSVDLT AGGFCAALE SLTNISSCN AIHRTQRIL NGLCNQKAS DVASSPPDT KIEVAQFIS KLLNYSKQL FRYGH
Research Interest: Innate Immunity, Adaptive Immunity, Stem Cell Research, Immunology, Cancer, Inflammation
Cell Type: Monocytes and Macrophages, T Cells
Protein Cross Reactivity: Human

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$1,040.00
500µg
$3,120.00
1mg
$5,200.00