Recombinant Rat IFN-γ
Catalog Number : 400-20
IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ is species-specific and is biologically active only in human and primate cells. Recombinant rat IFN-γ is a 15.6 kDa protein containing 135 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
Determined by its ability to inhibit the proliferation of mouse WEHI-279 cells.
MQGTLIESL ESLKNYFNS SSMDAMEGK SLLLDIWRN WQKDGNTKI LESQIISFY LRLFEVLKD NQAISNNIS VIESHLITN FFSNSKAKK DAFMSIAKF EVNNPQIQH KAVNELIRV IHQLSPESS LRKRKRSRC
|Research Interest:||Innate Immunity, Stem Cell Research, Immunology, Cancer, Angiogenesis, Neurosciences, Metabolic Regulation and Diabetes|
|Cell Type:||B Cells, Macrophage / Monocyte, NK and NKT Cells, T Cells, T Regulatory Cells|
|Protein Cross Reactivity:||Mouse|