Recombinant Rat Leptin

Grouped product items
SizePrice Qty
200µg
$80.00
1mg
$195.00
5mg
$500.00
Catalog Number : 400-21

description

Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Rat Leptin is a 16.2 kDa protein containing 147 amino acid residues.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
Mouse
Biological Activity
Determined by an in vivo assay using the ob/ob mouse obesity model and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5µg leptin/gm of body weight for 7 days. Significant effects on body weight, food consumpti
AA Sequence
MVPIHKVQD DTKTLIKTI VTRINDISH TQSVSARQR VTGLDFIPG LHPILSLSK MDQTLAVYQ QILTSLPSQ NVLQIAHDL ENLRDLLHL LAFSKSCSL PQTRGLQKP ESLDGVLEA SLYSTEVVA LSRLQGSLQ DILQQLDLS PEC
Research Interest:Apoptosis, Angiogenesis, Inflammation, Metabolic Regulation and Diabetes
Application:FA
Protein Cross Reactivity:Mouse
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