Recombinant Rat Leptin
Catalog Number : 400-21
Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Rat Leptin is a 16.2 kDa protein containing 147 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
Determined by an in vivo assay using the ob/ob mouse obesity model and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5µg leptin/gm of body weight for 7 days. Significant effects on body weight, food consumpti
MVPIHKVQD DTKTLIKTI VTRINDISH TQSVSARQR VTGLDFIPG LHPILSLSK MDQTLAVYQ QILTSLPSQ NVLQIAHDL ENLRDLLHL LAFSKSCSL PQTRGLQKP ESLDGVLEA SLYSTEVVA LSRLQGSLQ DILQQLDLS PEC
|Research Interest:||Apoptosis, Angiogenesis, Inflammation, Metabolic Regulation and Diabetes|
|Protein Cross Reactivity:||Mouse|