Recombinant Murine Midkine
Catalog Number : 315-25
Midkine and its functionally-related protein Pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK). MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development. MK chemoattracts embryonic neurons, neutrophils and macrophages, and by signaling through the ALK receptor it exerts angiogenic, growth and survival activities during tumorgenesis. Recombinant murine Midkine is a 13.3 kDa protein containing 120 amino acid residues including five intra-molecular disulfide bonds.
Above 98% as determined by SDS-PAGE Analysis.
Determined by its ability to chemoattract human neutrophils using a concentration range of 10-100 ng/ml.
VAKKKEKVK KGSECSEWT WGPCTPSSK DCGMGFREG TCGAQTQRV HCKVPCNWK KEFGADCKY KFESWGACD GSTGTKARQ GTLKKARYN AQCQETIRV TKPCTSKTK SKTKAKKGK GKD
|Research Interest:||Angiogenesis, Neurosciences|
|Cell Type:||Macrophage / Monocyte, Neurons|
|Protein Cross Reactivity:||NULL|