Recombinant Murine Leptin
Catalog Number : 450-31
Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant murine Leptin is a 16.2 kDa protein containing 147 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
Hamster, Human, Pig, Rat
PeproTech's murine Leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight f
MVPIQKVQD DTKTLIKTI VTRINDISH TQSVSAKQR VTGLDFIPG LHPILSLSK MDQTLAVYQ QVLTSLPSQ NVLQIANDL ENLRDLLHL LAFSKSCSL PQTSGLQKP ESLDGVLEA SLYSTEVVA LSRLQGSLQ DILQQLDVS PEC
|Research Interest:||Apoptosis, Angiogenesis, Inflammation, Metabolic Regulation and Diabetes|
|Protein Cross Reactivity:||Hamster, Human, Pig, Rat|