Recombinant Murine Cardiotrophin-1
Catalog Number : 250-25
CT-1 is a member of the IL-6 family of cytokines which also includes LIF, CNTF, OSM (Oncostatin M), IL-11, IL-6 and possibly NNT-1/BCSF-3. CT-1 is a pleiotropic cytokine which is expressed in various tissues including the adult heart, skeletal muscle, ovary, colon, prostate and fetal lung and signals through the LIF receptor and the gp130 receptor subunit. CT-1 has the ability to induce cardiac myocyte hypertrophy, and enhances the survival of cardiomyocyte and different neuronal populations. Recombinant murine Cardiotrophin-1 is a 21.3 kDa protein consisting of 202 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
SQREGSLED HQTDSSISF LPHLEAKIR QTHNLARLL TKYAEQLLE EYVQQQGEP FGLPGFSPP RLPLAGLSG PAPSHAGLP VSERLRQDA AALSVLPAL LDAVRRRQA ELNPRAPRL LRSLEDAAR QVRALGAAV ETVLAALGA AARGPGPEP VTVATLFTA NSTAGIFSA KVLGFHVCG LYGEWVSRT EGDLGQLVP GGVA
|Research Interest:||Angiogenesis, Neurosciences, Bone Biology|
|Protein Cross Reactivity:||Human|