Recombinant Murine Betacellulin
Catalog Number : 315-21
Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant murine Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.
Above 98% as determined by SDS-PAGE Analysis.
Determined by its ability to stimulate the proliferation of mouse Balb/3T3 cells. The expected ED50 is ≤ 0.01 ng/ml, corresponding to a specific activity of ≥ 1 x 108 units/mg.
DGNTTRTPE TNGSLCGAP GENCTGTTP RQKVKTHFS RCPKQYKHY CIHGRCRFV VDEQTPSCI CEKGYFGAR CERVDLFY
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