Recombinant Murine APRIL

Grouped product items
Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00
Catalog Number : 315-13

description

APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA. APRIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor. Recombinant murine APRIL is a soluble 21.9 kDa protein, consisting of 192 amino acid residues.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
Human
Biological Activity
Measured by its ability to induce cell proliferation of activated T cells.
AA Sequence
MRREVSRLQ RSGGPSQKQ GERPWQSLW EQSPDVLEA WKDGAKSRR RRAVLTQKH KKKHSVLHL VPVNITSKD SDVTEVMWQ PVLRRGRGL EAQGDIVRV WDTGIYLLY SQVLFHDVT FTMGQVVSR EGQGRRETL FRCIRSMPS DPDRAYNSC YSAGVFHLH QGDIITVKI PRANAKLSL SPHGTFLGF VKL
Research Interest: Adaptive Immunity, Apoptosis, Immunology, Cancer
Cell Type: B Cells, Macrophage / Monocyte, T Cells
Application: FA
Protein Cross Reactivity: Human
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