Recombinant Human WISP-3
Catalog Number : 120-20
WISP-3 is a member of the CCN family of secreted cysteine rich regulatory proteins. It is predominantly expressed in the adult kidney, testis and fetal kidney and weaker expression in placenta, ovary, prostate, small intestine, and skeletally-derived cells. WISP-3 is required for normal postnatal skeletal growth and cartilage homeostasis. Human WISP-3 is a 36.8 kDa protein containing 331 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the thrombospondin type-1 repeat (TSP type-1) domain, and a C-terminal cysteine knot-like (CTCK) domain.
Above 98% as determined by SDS-PAGE Analysis.
The ED50 was determined by the dose-dependant proliferation of the MCF-7 cell line. The expected ED50 for this effect is 0.2-0.3 µg/ml.
TGPLDTTPE GRPGEVSDA PQRKQFCHW PCKCPQQKP RCPPGVSLV RDGCGCCKI CAKQPGEIC NEADLCDPH KGLYCDYSV DRPRYETGV CAYLVAVGC EFNQVHYHN GQVFQPNPL FSCLCVSGA IGCTPLFIP KLAGSHCSG AKGGKKSDQ SNCSLEPLL QQLSTSYKT MPAYRNLPL IWKKKCLVQ ATKWTPCSR TCGMGISNR VTNENSNCE MRKEKRLCY IQPCDSNIL KTIKIPKGK TCQPTFQLS KAEKFVFSG CSSTQSYKP TFCGICLDK RCCIPNKSK MITIQFDCP NEGSFKWKM LWITSCVCQ RNCREPGDI FSELKIL
|Research Interest:||Angiogenesis, Bone Biology|
|Protein Cross Reactivity:||NULL|