Recombinant Human WISP-1
Catalog Number : 120-18
WISP-1 is a member of the CCN family of secreted cysteine rich regulatory proteins. It is expressed in the heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. WISP-1 is a β catenin regulated protein that can contribute to tumorigenesis and has also been shown to play a role in bone development and fracture repair. Human WISP-1 is a 38.1 kDa protein containing 346 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the thrombospondin type-1 repeat (TSP type-1) domain, and a C-terminal cysteine knot-like (CTCK) domain.
Above 98% as determined by SDS-PAGE Analysis.
The ED50 was determined by the dose-dependant proliferation of the MCF-7 cell line. The expected ED50 for this effect is 1.0-3.0 µg/ml.
TALSPAPTT MDFTPAPLE DTSSRPQFC KWPCECPPS PPRCPLGVS LITDGCECC KMCAQQLGD NCTEAAICD PHRGLYCDY SGDRPRYAI GVCAQVVGV GCVLDGVRY NNGQSFQPN CKYNCTCID GAVGCTPLC LRVRPPRLW CPHPRRVSI PGHCCEQWV CEDDAKRPR KTAPRDTGA FDAVGEVEA WHRNCIAYT SPWSPCSTS CGLGVSTRI SNVNAQCWP EQESRLCNL RPCDVDIHT LIKAGKKCL AVYQPEASM NFTLAGCIS TRSYQPKYC GVCMDNRCC IPYKSKTID VSFQCPDGL GFSRQVLWI NACFCNLSC RNPNDIFAD LESYPDFSE IAN
|Research Interest:||Cancer, Bone Biology|
|Protein Cross Reactivity:||Mouse, Rat|