Recombinant Human VAP-1
Catalog Number : 150-16
VAP-1 is a type II membrane cell adhesion protein belonging to the copper/topaquinone oxidase family. It is primarily expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. VAP-1 can catalyze the oxidative deamination of low molecular weight amines, and plays an important role in the migration of lymphocytes to inflamed tissue. Inhibition of VAP-1 can protect against inflammation related damage to certain injured tissues. Additionally, VAP-1 can function as a significant prognostic marker for certain cancers and cardiovascular diseases. Recombinant VAP-1 is a mixture of monomeric and disulfide linked homodimeric forms of a 737 amino acid polypeptide corresponding to amino acids 27 to 763 of the VAP-1 precursor.
Above 98% as determined by SDS-PAGE Analysis.
Measured by its ability to produce hydrogen peroxide during the oxidation of benzylamine. The specific activity >16 pMoles/min/µg of VAP-1.
GRGGDGGEP SQLPHCPSV SPSAQPWTH PGQSQLFAD LSREELTAV MRFLTQRLG PGLVDAAQA RPSDNCVFS VELQLPPKA AALAHLDRG SPPPAREAL AIVFFGRQP QPNVSELVV GPLPHPSYM RDVTVERHG GPLPYHRRP VLFQEYLDI DQMIFNREL PQASGLLHH CCFYKHRGR NLVTMTTAP RGLQSGDRA TWFGLYYNI SGAGFFLHH VGLELLVNH KALDPARWT IQKVFYQGR YYDSLAQLE AQFEAGLVN VVLIPDNGT GGSWSLKSP VPPGPAPPL QFYPQGPRF SVQGSRVAS SLWTFSFGL GAFSGPRIF DVRFQGERL VYEISLQEA LAIYGGNSP AAMTTRYVD GGFGMGKYT TPLTRGVDC PYLATYVDW HFLLESQAP KTIRDAFCV FEQNQGLPL RRHHSDLYS HYFGGLAET VLVVRSMST LLNYDYVWD TVFHPSGAI EIRFYATGY ISSAFLFGA TGKYGNQVS EHTLGTVHT HSAHFKVDL DVAGLENWV WAEDMVFVP MAVPWSPEH QLQRLQVTR KLLEMEEQA AFLVGSATP RYLYLASNH SNKWGHPRG YRIQMLSFA GEPLPQNSS MARGFSWER YQLAVTQRK EEEPSSSSV FNQNDPWAP TVDFSDFIN NETIAGKDL VAWVTAGFL HIPHAEDIP NTVTVGNGV GFFLRPYNF FDEDPSFYS ADSIYFRGD QDAGACEVN PLACLPQAA ACAPDLPAF SHGGFSHN
|Research Interest:||Innate Immunity, Cancer, Angiogenesis, Inflammation|
|Cell Type:||Endothelial Cells|
|Protein Cross Reactivity:||NULL|