Recombinant Human TWEAK
Catalog Number : 310-06
description
TWEAK belongs to the TNF family of ligands and signals through TWEAKR also known as TNFRSF12A. TWEAK is expressed in a variety of tissues, including the adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. TWEAK has the ability to induce NFkB activation and chemokine secretion, and to exert an apoptotic activity in certain cells, such as HT-29 human adenocarcinoma cells when cultured in the presence of IFN-γ. TWEAK also promotes proliferation and migration of endothelial cells. Recombinant human TWEAK is a soluble 17.0 kDa polypeptide (154 amino acid residues) comprising the TNF homologous region of TWEAK and is generated by proteolytic processing of the full length membrane anchored TWEAK protein.
Additional Information
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Source:
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E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity:
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Mouse
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Biological Activity
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Assay #1: The ED50 as determined by the dose-dependent stimulation of IL-8 production by Human PBMC is less than 10 ng/ml.
Assay #2: TWEAK weakly induces the death of HT29 cells when cul |
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AA Sequence
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MKGRKTRAR RAIAAHYEV HPRPGQDGA QAGVDGTVS GWEEARINS SSPLRYNRQ IGEFIVTRA GLYYLYCQV HFDEGKAVY LKLDLLVDG VLALRCLEE FSATAASSL GPQLRLCQV SGLLALRPG SSLRIRTLP WAHLKAAPF LTYFGLFQV H
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| Research Interest: | Apoptosis, Angiogenesis, Neurosciences, Inflammation, Proliferation and Cell Cycle |
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| Cell Type: | B Cells, Macrophage / Monocyte, T Cells, Endothelial Cells |
| Application: | FA |
| Protein Cross Reactivity: | Mouse |