Recombinant Human TWEAK Receptor
Catalog Number : 310-21
description
TWEAKR belongs to the TNF family of transmembrane proteins and contains a cytoplasmic "death domain", which can activated the cell's apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAKR can be activated by either the membrane anchored or the soluble TWEAK. Recombinant soluble TWEAKR is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAKR protein.
Additional Information
Source: | E. Coli |
Purity: | Above 98% as determined by SDS-PAGE Analysis. |
Cross Reactivity: | NULL |
Biological Activity | Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-3.0 µg/ml. |
AA Sequence | EQAPGTAPC SRGSSWSAD LDKCMDCAS CRARPHSDF CLGCAAAPP APFRLLWP |
| Research Interest: | Apoptosis, Receptors |
|---|---|
| Cell Type: | T Cells |
| Application: | FA |
| Protein Cross Reactivity: | NULL |