Recombinant Human TSLP
Catalog Number : 300-62
TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R α chain (IL-7Rα) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (DCs). TSLP activated DCs primed naïve T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFα) while down-regulating IL-10 and IFN-γ suggesting a role in initiating allergic inflammation. Recombinant human TSLP is a 15.0 kDa protein consisting of 132 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
Data not available at this time.
MYDFTNCDF EKIKAAYLS TISKDLITY MSGTKSTEF NNTVSCSNR PHCLTEIQS LTFNPTAGC ASLAKEMFA MKTKAALAI WCPGYSETQ INATQAMKK RRKRKVTTN KCLEQVSQL QGLWRRFNR PLLKQQ
|Research Interest:||Innate Immunity, Apoptosis, Inflammation|
|Cell Type:||Macrophage / Monocyte, T Cells, Dendritic Cells|
|Protein Cross Reactivity:||NULL|