Recombinant Human TSG
Catalog Number : 120-09
description
Twisted Gastrulation Protein (TSG) is a secreted BMP binding protein structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins, and can act either as a BMP4 agonist or antagonist (depending on the specific biochemical environment) by binding to the BMP4/Chordin complex. Recombinant human TSG is a 198 amino acid 22.2 kDa protein containing the BMP/TGFβ binding portion of the full length TSG protein.
Additional Information
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Source:
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E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity:
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Mouse
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Biological Activity
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Determined by its ability to neutralize BMP-6 induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED50 for this effect is < 2.0 μg/ml of TSG.
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AA Sequence
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CNKALCASD VSKCLIQEL CQCRPGEGN CSCCKECML CLGALWDEC CDCVGMCNP RNYSDTPPT SKSTVEELH EPIPSLFRA LTEGDTQLN WNIVSFPVA EELSHHENL VSFLETVNQ PHHQNVSVP SNNVHAPYS SDKEHMCTV VYFDDCMSI HQCKISCES MGASKYRWF HNACCECIG PECIDYGSK TVKCMNCMF
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| Application: | FA |
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| Protein Cross Reactivity: | Mouse |