Recombinant Human TPO
Catalog Number : 300-18
TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein.
Above 98% as determined by SDS-PAGE Analysis.
The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
SPAPPACDL RVLSKLLRD SHVLHSRLS QCPEVHPLP TPVLLPAVD FSLGEWKTQ MEETKAQDI LGAVTLLLE GVMAARGQL GPTCLSSLL GQLSGQVRL LLGALQSLL GTQLPPQGR TTAHKDPNA IFLSFQHLL RGKVRFLML VGGSTLCVR RAPPTTAVP SRTSLVLTL NEL
|Research Interest:||Stem Cell Research, Proliferation and Cell Cycle|
|Protein Cross Reactivity:||Monkey, Mouse|