Recombinant Human TL-1A
Catalog Number : 310-23
description
TL-1A belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells, and to a lesser extent in placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. TL-1A inhibits endothelial cell proliferation and angiogenesis, and has been shown to induce NFkB activation, caspase activity, and apoptosis in responding cell lines. TL-1A interacts with TNFRSF25/DR3 receptor, but can also bind to a decoy receptor TNFRSF21/DR6. Recombinant human TL-1A is a 22.0 kDa polypeptide of 194 amino acid residues.
Additional Information
Source: | E. Coli |
Purity: | Above 98% as determined by SDS-PAGE Analysis. |
Cross Reactivity: | NULL |
Biological Activity | Determined by its ability to stimulate IFN-γ production by human PBMC using a concentration range of 10.0-100.0 ng/ml. Note: Results may vary with PBMC donors. |
AA Sequence | QLRAQGEAS VQFQALKGQ EFAPSHQQV YAPLRADGD KPRAHLTVV RQTPTQHFK NQFPALHWE HELGLAFTK NRMNYTNKF LLIPESGDY FIYSQVTFR GMTSECSEI RQAGRPNKP DSITVVITK VTDSYPEPT QLLMGTKSV CEVGSNWFQ PIYLGAMFS LQEGDKLMV NVSDISLVD YTKEDKTFF GAFLL |
| Research Interest: | Apoptosis, Angiogenesis |
|---|---|
| Cell Type: | Endothelial Cells |
| Application: | FA |
| Protein Cross Reactivity: | NULL |