Recombinant Human SPARC/Osteonectin
Catalog Number : 120-36
SPARC/Osteonectin is a secreted, evolutionarily conserved collagen-binding glycoprotein that is involved in a variety of cellular activities. It is highly expressed in tissues undergoing morphogenesis, remodeling and wound repair. SPARC/Osteonectin and its related peptides bind to numerous proteins of the extracellular matrix (ECM), affect ECM protein expression, influence cellular adhesion and migration, and modulate growth factor-induced cell proliferation and angiogenesis. SPARC/Osteonectin consists of three domains; an N-terminal acidic region that binds calcium ions with low affinity, a module containing two EF-hand motifs that bind calcium with high affinity, and a cysteine-rich follistatin-like domain. Recombinant human SPARC/Osteonectin is a glycoprotein containing 286 amino acids that migrates at an apparent MW of 43.7 kDa by SDS-PAGE analysis due to the effect of glycosylation.
Above 98% as determined by SDS-PAGE Analysis.
Determined by its ability to increase alkaline phosphatase activity in differentiating MC3T3 cells using a concentration of 0.5-0.7 μg/ml.
APQQEALPD ETEVVEETV AEVTEVSVG ANPVQVEVG EFDDGAEET EEEVVAENP CQNHHCKHG KVCELDENN TPMCVCQDP TSCPAPIGE FEKVCSNDN KTFDSSCHF FATKCTLEG TKKGHKLHL DYIGPCKYI PPCLDSELT EFPLRMRDW LKNVLVTLY ERDEDNNLL TEKQKLRVK KIHENEKRL EAGDHPVEL LARDFEKNY NMYIFPVHW QFGQLDQHP IDGYLSHTE LAPLRAPLI PMEHCTTRF FETCDLDND KYIALDEWA GCFGIKQKD IDKDLVI
|Research Interest:||Cancer, Angiogenesis, Bone Biology, Proliferation and Cell Cycle|
|Protein Cross Reactivity:||NULL|