Recombinant Human Slit2-N
Catalog Number : 150-11
Slit2 is a member of the Slit family that signals through the Roundabout (Robo) receptor as a repellent for axon guidance and neuronal migration, and can also act as a chemoattractant to vascular endothelial cells and a chemotaxis inhibitor for leukocytes. Slit2 is expressed primarily in the fetal lung, kidney, and adult spinal cord, and to a lesser extent in adult adrenal gland, thyroid and trachea. Slit2 is initially synthesized as a 1499 amino acid precursor, which is subsequently cleaved into N-terminal and C-terminal fragments, designated as Slit2-N and Slit2-C respectively. The neurodevelopment related activities, as measured by the ability to repel olfactory bulb axons and to induce branching in dorsal root ganglia axons, are contained only in the N-terminal fragment. Recombinant human Slit2-N is a 1093 amino acid glycoprotein corresponding to the N-terminal portion of the full length Slit2 precursor. Due to glycosylation Slit2-N migrates at an apparent molecular weight of approximately 120.0-140.0 kDa by SDS-PAGE analysis under reducing conditions.
Above 98% as determined by SDS-PAGE Analysis.
Determined by its ability to inhibit MC3T3/E1 osteoblasts cell differentiation.
QACPAQCSC SGSTVDCHG LALRSVPRN IPRNTERLD LNGNNITRI TKTDFAGLR HLRVLQLME NKISTIERG AFQDLKELE RLRLNRNHL QLFPELLFL GTAKLYRLD LSENQIQAI PRKAFRGAV DIKNLQLDY NQISCIEDG AFRALRDLE VLTLNNNNI TRLSVASFN HMPKLRTFR LHSNNLYCD CHLAWLSDW LRQRPRVGL YTQCMGPSH LRGHNVAEV QKREFVCSG HQSFMAPSC SVLHCPAAC TCSNNIVDC RGKGLTEIP TNLPETITE IRLEQNTIK VIPPGAFSP YKKLRRIDL SNNQISELA PDAFQGLRS LNSLVLYGN KITELPKSL FEGLFSLQL LLLNANKIN CLRVDAFQD LHNLNLLSL YDNKLQTIA KGTFSPLRA IQTMHLAQN PFICDCHLK WLADYLHTN PIETSGARC TSPRRLANK RIGQIKSKK FRCSAKEQY FIPGTEDYR SKLSGDCFA DLACPEKCR CEGTTVDCS NQKLNKIPE HIPQYTAEL RLNNNEFTV LEATGIFKK LPQLRKINF SNNKITDIE EGAFEGASG VNEILLTSN RLENVQHKM FKGLESLKT LMLRSNRIT CVGNDSFIG LSSVRLLSL YDNQITTVA PGAFDTLHS LSTLNLLAN PFNCNCYLA WLGEWLRKK RIVTGNPRC QKPYFLKEI PIQDVAIQD FTCDDGNDD NSCSPLSRC PTECTCLDT VVRCSNKGL KVLPKGIPR DVTELYLDG NQFTLVPKE LSNYKHLTL IDLSNNRIS TLSNQSFSN MTQLLTLIL SYNRLRCIP PRTFDGLKS LRLLSLHGN DISVVPEGA FNDLSALSH LAIGANPLY CDCNMQWLS DWVKSEYKE PGIARCAGP GEMADKLLL TTPSKKFTC QGPVDVNIL AKCNPCLSN PCKNDGTCN SDPVDFYRC TCPYGFKGQ DCDVPIHAC ISNPCKHGG TCHLKEGEE DGFWCICAD GFEGENCEV NVDDCEDND CENNSTCVD GINNYTCLC PPEYTGELC EEKLDFCAQ DLNPCQHDS KCILTPKGF KCDCTPGYV GEHCDIDFD DCQDNKCKN GAHCTDAVN GYTCICPEG YSGLFCEFS PPMV
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