Recombinant Human sDLL-1
Catalog Number : 140-08
Human sDLL-1 comprises the extracellular signaling domain of DLL1, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. It is expressed in the heart and pancreas, and to a lesser extent in various other tissues. DLL-1 functions to specifically activate the Notch-1 and Notch-2 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. DLL-1 suppresses differentiation of hematopoietic progenitor cells into the B-cell lineage while promoting differentiation to T-cell and NK cell precursors. Recombinant human sDLL-1 is a 57.0-60.0 kDa glycoprotein containing 522 amino-acid residues.
Above 95% as determined by SDS-PAGE Analysis.
Determined by the dose dependent growth suppression of the human acute monocytic leukemia cell line, THP-1. sDLL-1 inhibits the proliferation in THP-1 cells using a concentration of 3.0-5.0 μg/ml.
SGVFELKLQ EFVNKKGLL GNRNCCRGG AGPPPCACR TFFRVCLKH YQASVSPEP PCTYGSAVT PVLGVDSFS LPDGGGADS AFSNPIRFP FGFTWPGTF SLIIEALHT DSPDDLATE NPERLISRL ATQRHLTVG EEWSQDLHS SGRTDLKYS YRFVCDEHY YGEGCSVFC RPRDDAFGH FTCGERGEK VCNPGWKGP YCTEPICLP GCDEQHGFC DKPGECKCR VGWQGRYCD ECIRYPGCL HGTCQQPWQ CNCQEGWGG LFCNQDLNY CTHHKPCKN GATCTNTGQ GSYTCSCRP GYTGATCEL GIDECDPSP CKNGGSCTD LENSYSCTC PPGFYGKIC ELSAMTCAD GPCFNGGRC SDSPDGGYS CRCPVGYSG FNCEKKIDY CSSSPCSNG AKCVDLGDA YLCRCQAGF SGRHCDDNV DDCASSPCA NGGTCRDGV NDFSCTCPP GYTGRNCSA PVSRCEHAP CHNGATCHE RGHRYVCEC ARGYGGPNC QFLLPELPP GPAVVDLTE KLEGQGGPF
|Research Interest:||Apoptosis, Angiogenesis, Proliferation and Cell Cycle|
|Cell Type:||NK and NKT Cells, T Cells, Endothelial Cells|
|Protein Cross Reactivity:||NULL|