Recombinant Human sCD30 Ligand

Grouped product items
Size Price Qty
10µg
$80.00
50µg
$195.00
100µg
$300.00
500µg
$900.00
1mg
$1,500.00
Catalog Number : 450-42

description

CD30 ligand (CD30L) is a type-II membrane-associated glycoprotein protein belonging to the TNF superfamily and is expressed primarily on certain B cells, T cells, and monocytes. CD30L binds specifically to CD30 (receptor), which is expressed on activated, but not resting, B and T cells, in lymphomas and various chronically inflamed tissues. CD30L/CD30 interactions initiate a signaling cascade that can ultimately lead to the activation of NF-KappaB. CD30L/CD30 signaling exerts pleiotropic effects on normal cells, including cell death, differentiation, or cell division. Certain diseases, including Hodgkins’s lymphoma, allergic inflammation, diabetes (in NOD mice), and mycobacterial infection can also be affected by CD30L/CD30 signaling. The CD30L gene encodes for a 234 amino acid type II transmembrane protein, which contains a 37 amino acid cytoplasmic sequence, a 25 amino acid transmembrane domain and a 172 amino acid extracellular domain. Recombinant human soluble CD30L (sCD30L) is a 188 amino acid polypeptide corresponding to the extracellular domain, and contains an 8 residue N-terminal His -Tag.

Additional Information

Source:
CHO cells
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
NULL
Biological Activity
Determined by its ability to stimulate human IL-8 production by human PBMC using a concentration range of 10.0-25.0 ng/ml. Note: Results may vary with PBMC donors.
AA Sequence
HHHHHHHHP SPGGSGGQR TDSIPNSPD NVPLKGGNC SEDLLCILK RAPFKKSWA YLQVAKHLN KTKLSWNKD GILHGVRYQ DGNLVIQFP GLYFIICQL QFLVQCPNN SVDLKLELL INKHIKKQA LVTVCESGM QTKHVYQNL SQFLLDYLQ VNTTISVNV DTFQYIDTS TFPLENVLS IFLYSNSD
Research Interest: Immunology, Cancer, Inflammation, Metabolic Regulation and Diabetes
Cell Type: B Cells, Macrophage / Monocyte, T Cells
Application: FA
Protein Cross Reactivity: NULL
© BioGems International, Inc. All rights reserved.