Recombinant Human sCD27 Ligand
Catalog Number : 310-30
CD27 Ligand, a type II transmembrane protein, is a member of the TNF superfamily. It is expressed on activated T and B lymphocytes as well as NK cells. CD27L and its receptor (CD27) regulate the immune response by promoting T-cell expansion and differentiation, as well as NK enhancement. CD27 signaling can act as a co-stimulatory effector to sustain the survival of CD8+ T cells, primarily by inducing increased expression of the IL-2 gene. Full length human CD27L is a 193 amino acid protein, consisting of a 17 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 155 amino acid extracellular domain. Human soluble CD27L corresponds to the 155 amino acid extracellular domain of the full length CD27L protein. The recombinant human sCD27L contains the extracellular domain plus an N-terminal His-Tag.
Above 95% as determined by SDS-PAGE Analysis.
Determined by its ability to stimulate human IL-8 production by human PBMC using a concentration range of 10.0-25.0 ng/ml. Note: Results may vary with PBMC donors.
HHHHHHHHP SPGGSGGQR FAQAQQQLP LESLGWDVA ELQLNHTGP QQDPRLYWQ GGPALGRSF LHGPELDKG QLRIHRDGI YMVHIQVTL AICSSTTAS RHHPTTLAV GICSPASRS ISLLRLSFH QGCTIASQR LTPLARGDT LCTNLTGTL LPSRNTDET FFGVQWVRP
|Research Interest:||Innate Immunity, Adaptive Immunity, Immunology|
|Cell Type:||B Cells, NK and NKT Cells, T Cells|
|Protein Cross Reactivity:||NULL|