Recombinant Human sCD23

Grouped product items
Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00
Catalog Number : 310-26

description

CD23, the low affinity receptor for IgE, belongs to the C-type lectin structural family and plays a role in the regulation of IgE synthesis and IgE mediated activities. It is found both as a transmembrane receptor protein and in a soluble form, which is generated by proteolytic cleavage of membrane bound CD23. The predominant soluble form of CD23 (sCD23) consists of 172 amino acids corresponding to the extracellular domain of the full length precursor. sCD23, in addition to binding IgE, also exerts a number of IgE independent activities, such as promoting the activation and differentiation of B-cells and stimulating the release of pro-inflammatory cytokines from monocytes. Recombinant human sCD23 is a 19.2 kDa non-glycosylated protein containing 172 amino-acid residues.

Additional Information

Source:
E. Coli
Purity:
Above 96% as determined by SDS-PAGE Analysis.
Cross Reactivity:
NULL
Biological Activity
Measured by its ability to induce TNF-alpha production by human PBMCs.
AA Sequence
MELQVSSGF VCNTCPEKW INFQRKCYY FGKGTKQWV HARYACDDM EGQLVSIHS PEEQDFLTK HASHTGSWI GLRNLDLKG EFIWVDGSH VDYSNWAPG EPTSRSQGE DCVMMRGSG RWNDAFCDR KLGAWVCDR LATCTPPAS EGSAESMGP DSRPDPDGR LPTPSAPLH S
Research Interest: Innate Immunity, Adaptive Immunity, Receptors
Cell Type: B Cells, Macrophage / Monocyte
Application: FA
Protein Cross Reactivity: NULL
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