Recombinant Human sCD22
Catalog Number : 100-01
CD22 is a B-lineage restricted 135 kDa glycoprotein whose cell surface expression is limited to resting and activated B lymphocytes. The physiological role of CD22 is still unknown. Targeted disruption of CD22 in mice results in a reduced level of surface IgM on peripheral B cells suggesting a role for CD22 in limiting antigen receptor signaling. CD22 is a member of the Ig gene superfamily that uniquely binds a sialic acid-dependent ligand. Recombinant human CD22 is a soluble 75.0 kDa protein which corresponds to the extracellular domain of CD22.
Above 98% as determined by SDS-PAGE Analysis.
Determined by its ability to inhibit the proliferation of Raji cells. The expected ED50 for this effect is 10-17 μg/ml.
SKWVFEHPE TLYAWEGAC VWIPCTYRA LDGDLESFI LFHNPEYNK NTSKFDGTR LYESTKDGK VPSEQKRVQ FLGDKNKNC TLSIHPVHL NDSGQLGLR MESKTEKWM ERIHLNVSE RPFPPHIQL PPEIQESQE VTLTCLLNF SCYGYPIQL QWLLEGVPM RQAAVTSTS LTIKSVFTR SELKFSPQW SHHGKIVTC QLQDADGKF LSNDTVQLN VKHTPKLEI KVTPSDAIV REGDSVTMT CEVSSSNPE YTTVSWLKD GTSLKKQNT FTLNLREVT KDQSGKYCC QVSNDVGPG RSEEVFLQV QYAPEPSTV QILHSPAVE GSQVEFLCM SLANPLPTN YTWYHNGKE MQGRTEEKV HIPKILPWH AGTYSCVAE NILGTGQRG PGAELDVQY PPKKVTTVI QNPMPIREG DTVTLSCNY NSSNPSVTR YEWKPHGAW EEPSLGVLK IQNVGWDNT TIACARCNS WCSWASPVA LNVQYAPRD VRVRKIKPL SEIHSGNSV SLQCDFSSS HPKEVQFFW EKNGRLLGK ESQLNFDSI SPEDAGSYS CWVNNSIGQ TASKAWTLE VLYAPRRLR VSMSPGDQV MEGKSATLT CESDANPPV SHYTWFDWN NQSLPHHSQ KLRLEPVKV QHSGAYWCQ GTNSVGKGR SPLSTLTVY YSPETIGRR
|Research Interest:||Innate Immunity, Adaptive Immunity, Cancer|
|Cell Type:||B Cells|
|Protein Cross Reactivity:||NULL|