Recombinant Human R-Spondin-3
Catalog Number : 120-44
The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization and resulting accumulation of the intracellular signaling protein, β-catenin. This activity effectively activates and increases the subsequent nuclear signaling of β-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/β-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations. Recombinant human R-Spondin-3 is a 26.9 kDa protein consisting of 240 amino acid residues. Due to glycosylation, R-Spondin-3 migrates at an apparent molecular weight of approximately 37.0 kDa by SDS PAGE analysis under reducing conditions.
Above 95% as determined by SDS-PAGE Analysis.
R-Spondin-3 enhances BMP-2 mediated differentiation of MC3T3-E1 cells.
MHPNVSQGC QGGCATCSD YNGCLSCKP RLFFALERI GMKQIGVCL SSCPSGYYG TRYPDINKC TKCKADCDT CFNKNFCTK CKSGFYLHL GKCLDNCPE GLEANNHTM ECVSIVHCE VSEWNPWSP CTKKGKTCG FKRGTETRV REIIQHPSA KGNLCPPTN ETRKCTVQR KKCQKGERG KKGRERKRK KPNKGESKE AIPDSKSLE SSKEIPEQR ENKQQQKKR KVQDKQKSV SVSTVH
|Research Interest:||Stem Cell Research, Cancer, Angiogenesis, Proliferation and Cell Cycle|
|Protein Cross Reactivity:||NULL|