Recombinant Human NT-3

Grouped product items
SizePrice Qty
2µg
$80.00
10µg
$195.00
100µg
$1,040.00
500µg
$3,120.00
1mg
$5,200.00
Catalog Number : 450-03

description

NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers (240 total amino acid residues). Human and Mouse NT-3 sequences are identical.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
Chicken, Cow, Dog, Frog, Hamster, Mouse, Pig, Rat
Biological Activity
The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml.
AA Sequence
MYAEHKSHR GEYSVCDSE SLWVTDKSS AIDIRGHQV TVLGEIKTG NSPVKQYFY ETRCKEARP VKNGCRGID DKHWNSQCK TSQTYVRAL TSENNKLVG WRWIRIDTS CVCALSRKI GRT
Research Interest:Stem Cell Research, Neurosciences
Cell Type:Neurons
Application:FA
Protein Cross Reactivity:Chicken, Cow, Dog, Frog, Hamster, Mouse, Pig, Rat
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