Recombinant Human NT-3
Catalog Number : 450-03
NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers (240 total amino acid residues). Human and Mouse NT-3 sequences are identical.
Above 98% as determined by SDS-PAGE Analysis.
Chicken, Cow, Dog, Frog, Hamster, Mouse, Pig, Rat
The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml.
MYAEHKSHR GEYSVCDSE SLWVTDKSS AIDIRGHQV TVLGEIKTG NSPVKQYFY ETRCKEARP VKNGCRGID DKHWNSQCK TSQTYVRAL TSENNKLVG WRWIRIDTS CVCALSRKI GRT
|Research Interest:||Stem Cell Research, Neurosciences|
|Protein Cross Reactivity:||Chicken, Cow, Dog, Frog, Hamster, Mouse, Pig, Rat|