Recombinant Human NOV
Catalog Number : 120-26
NOV is a member of the CCN family of secreted cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm’s tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorgenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell surface integrins and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities. Recombinant human NOV is a 36.2 kDa protein containing 331 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).
Above 95% as determined by SDS-PAGE Analysis.
Determined by a cell proliferation assay using BALB/c 3T3 cells. The expected ED50 for this effect is 1.0-2.0 μg/ml
MQVAATQRC PPQCPGRCP ATPPTCAPG VRAVLDGCS CCLVCARQR GESCSDLEP CDESSGLYC DRSADPSNQ TGICTAVEG DNCVFDGVI YRSGEKFQP SCKFQCTCR DGQIGCVPR CQLDVLLPE PNCPAPRKV EVPGECCEK WICGPDEED SLGGLTLAA YRPEATLGV EVSDSSVNC IEQTTEWTA CSKSCGMGF STRVTNRNR QCEMLKQTR LCMVRPCEQ EPEQPTDKK GKKCLRTKK SLKAIHLQF KNCTSLHTY KPRFCGVCS DGRCCTPHN TKTIQAEFQ CSPGQIVKK PVMVIGTCT CHTNCPKNN EAFLQELEL KTTRGKM
|Research Interest:||Cancer, Angiogenesis, Proliferation and Cell Cycle|
|Protein Cross Reactivity:||Mouse|