Recombinant Human Myostatin-Propeptide
Catalog Number : 120-12
description
Mature Myostatin is obtained by proteolytic processing of a biologically-inactive precursor protein, which contains an N-terminal propeptide of 243 amino acid residues. Myostatin Propeptide exhibits high binding affinity for myostatin and has been shown to be a potent inhibitor of Myostatin. Over-expression of myostatin propeptide in mice resulted in large increases (up to 200%) in skeletal muscle mass, similar to those observed in Myostatin knockout mice. Recombinant Human Myostatin Propeptide is a 27.8 kDa protein consisting of 244 amino acid residues.
Additional Information
Source: | E. Coli |
Purity: | Above 98% as determined by SDS-PAGE Analysis. |
Cross Reactivity: | Mouse |
Biological Activity | Determined by its ability to neutralize the Myostatin inhibitory effect of murine MPC-11 cells. The expected ED50 is 0.01–0.04 μg/ml in the presence of 50 ng/ml Myostatin. |
AA Sequence | MNENSEQKE NVEKEGLCN ACTWRQNTK SSRIEAIKI QILSKLRLE TAPNISKDV IRQLLPKAP PLRELIDQY DVQRDDSSD GSLEDDDYH ATTETIITM PTESDFLMQ VDGKPKCCF FKFSSKIQY NKVVKAQLW IYLRPVETP TTVFVQILR LIKPMKDGT RYTGIRSLK LDMNPGTGI WQSIDVKTV LQNWLKQPE SNLGIEIKA LDENGHDLA VTFPGPGED GLNPFLEVK VTDTPKRSR R |
| Research Interest: | Angiogenesis, Bone Biology, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes |
|---|---|
| Application: | FA |
| Protein Cross Reactivity: | Mouse |