Recombinant Human/Murine/Rat Myostatin
Catalog Number : 120-00
Myostatin is a TGF-β family member that acts as an inhibitor of skeletal muscle growth. This muscle-specific cytokine interacts with Activin type I and type II receptors, and suppresses myoblast proliferation by arresting cell-cycle in the G1 phase. Suppression of myostatin activity facilitates muscle formation and may be useful in reducing and/or preventing adiposity and type-2 diabetes. Myostatin activity can be blocked by the Activin-binding protein Follistatin, and by the propeptide of Myostatin. Recombinant Human myostatin is a 25.0 kDa protein consisting of two identical 109 amino acid polypeptides linked by a single disulfide bond.
Above 98% as determined by SDS-PAGE Analysis.
Determined by its ability to inhibit the proliferation of MPC-11 cells. The expected ED50 for this effect is 17.0-25.0 ng/ml.
DFGLDCDEH STESRCCRY PLTVDFEAF GWDWIIAPK RYKANYCSG ECEFVFLQK YPHTHLVHQ ANPRGSAGP CCTPTKMSP INMLYFNGK EQIIYGKIP AMVVDRCGC S
|Research Interest:||Angiogenesis, Bone Biology, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes|
|Protein Cross Reactivity:||Mouse, Rat|