Recombinant Human MANF

Grouped product items
SizePrice Qty
5µg
$80.00
25µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00
Catalog Number : 450-06

description

MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. MANF and its structural homolog CDNF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human MANF is an 18.1 kDa protein consisting of 158 amino acids including 8 cysteine residues.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
NULL
Biological Activity
Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/ml.
AA Sequence
LRPGDCEVC ISYLGRFYQ DLKDRDVTF SPATIENEL IKFCREARG KENRLCYYI GATDDAATK IINEVSKPL AHHIPVEKI CEKLKKKDS QICELKYDK QIDLSTVDL KKLRVKELK KILDDWGET CKGCAEKSD YIRKINELM PKYAPKAAS ARTDL
Research Interest:Neurosciences
Cell Type:Neurons
Application:FA
Protein Cross Reactivity:NULL
© BioGems International, Inc. All rights reserved.