Recombinant Human MANF
Catalog Number : 450-06
MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. MANF and its structural homolog CDNF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human MANF is an 18.1 kDa protein consisting of 158 amino acids including 8 cysteine residues.
Above 98% as determined by SDS-PAGE Analysis.
Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/ml.
LRPGDCEVC ISYLGRFYQ DLKDRDVTF SPATIENEL IKFCREARG KENRLCYYI GATDDAATK IINEVSKPL AHHIPVEKI CEKLKKKDS QICELKYDK QIDLSTVDL KKLRVKELK KILDDWGET CKGCAEKSD YIRKINELM PKYAPKAAS ARTDL
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