Recombinant Human Leptin

Grouped product items
SizePrice Qty
200µg
$80.00
1mg
$195.00
5mg
$500.00
Catalog Number : 300-27

description

Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant human Leptin is a 16.0 kDa protein containing 147 amino acid residues.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
Chicken, Monkey, Mouse, Rat
Biological Activity
PeproTech's human Leptin is biologically active in the ob/ob mouse obesity model. The ob/ob mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on bo
AA Sequence
MVPIQKVQD DTKTLIKTI VTRINDISH TQSVSSKQK VTGLDFIPG LHPILTLSK MDQTLAVYQ QILTSMPSR NVIQISNDL ENLRDLLHV LAFSKSCHL PWASGLETL DSLGGVLEA SGYSTEVVA LSRLQGSLQ DMLWQLDLS PGC
Research Interest:Apoptosis, Angiogenesis, Inflammation, Metabolic Regulation and Diabetes
Application:FA
Protein Cross Reactivity:Chicken, Monkey, Mouse, Rat
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