Recombinant Human Leptin
Catalog Number : 300-27
Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant human Leptin is a 16.0 kDa protein containing 147 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
Chicken, Monkey, Mouse, Rat
PeproTech's human Leptin is biologically active in the ob/ob mouse obesity model. The ob/ob mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on bo
MVPIQKVQD DTKTLIKTI VTRINDISH TQSVSSKQK VTGLDFIPG LHPILTLSK MDQTLAVYQ QILTSMPSR NVIQISNDL ENLRDLLHV LAFSKSCHL PWASGLETL DSLGGVLEA SGYSTEVVA LSRLQGSLQ DMLWQLDLS PGC
|Research Interest:||Apoptosis, Angiogenesis, Inflammation, Metabolic Regulation and Diabetes|
|Protein Cross Reactivity:||Chicken, Monkey, Mouse, Rat|