Recombinant Human Gremlin-1

Grouped product items
Size Price Qty
10µg
$80.00
50µg
$195.00
100µg
$300.00
500µg
$900.00
1mg
$1,500.00
Catalog Number : 120-42

description

Gremlin-1 (isoform-1) belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Gremlin is highly expressed in the small intestine, fetal brain, and colon and lower expression in brain, prostate, pancreas and skeletal muscle.  Gremlin-1 regulates multiple functions in early development by specifically binding to and inhibiting the function of BMP-2, -4, and -7.  It also plays a role in carcinogenesis and kidney branching morphogenesis. Recombinant Gremlin-1 is a 18.3  kDa protein containing 160 amino acid residues.

Additional Information

Source:
CHO cells
Purity:
Above 90% as determined by SDS-PAGE Analysis.
Cross Reactivity:
NULL
Biological Activity
Determined by its ability to inhibit BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells.  The ED50 for this effect is 0.07-0.11 μg/ml.
AA Sequence
KKKGSQGAI PPPDKAQHN DSEQTQSPQ QPGSRNRGR GQGRGTAMP GEEVLESSQ EALHVTERK YLKRDWCKT QPLKQTIHE EGCNSRTII NRFCYGQCN SFYIPRHIR KEEGSFQSC SFCKPKKFT TMMVTLNCP ELQPPTKKK RVTRVKQCR CISIDLD
Research Interest: Stem Cell Research, Cancer
Cell Type: Stem Cells, Neurons
Application: FA
Protein Cross Reactivity: NULL
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