Recombinant Human GDF-2
Catalog Number : 120-07
GDF-2 belongs to the TGF-β cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-2 is expressed mainly in nonparenchymal cells of the liver, but is also found in other various cells and tissues. GDF-2 can signal through the ALK1 receptor and has been implicated in a number of physiologic events. These include regulation of the hepatic reticuloendothelial system, glucose homeostasis, and iron homeostasis, as well as the inhibition of angiogenesis. Recombinant human GDF-2 is a 24.1 kDa disulfide linked homodimeric protein consisting of two 110 amino acid polypeptide chains.
Above 95% as determined by SDS-PAGE Analysis.
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.9 ng/ml.
SAGAGSHCQ KTSLRVNFE DIGWDSWII APKEYEAYE CKGGCFFPL ADDVTPTKH AIVQTLVHL KFPTKVGKA CCVPTKLSP ISVLYKDDM GVPTLKYHY EGMSVAECG CR
|Research Interest:||Angiogenesis, Neurosciences, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes|
|Protein Cross Reactivity:||Mouse|