Recombinant Human Flt3-Ligand
Catalog Number : 300-19
Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand exerts no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant human Flt3-Ligand is a soluble 17.6 kDa protein consisting of 155 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
Monkey, Mouse, Rat
The ED50 was determined by the dose-dependent stimulation of the proliferation of human AML5 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
TQDCSFQHS PISSDFAVK IRELSDYLL QDYPVTVAS NLQDEELCG GLWRLVLAQ RWMERLKTV AGSKMQGLL ERVNTEIHF VTKCAFQPP PSCLRFVQT NISRLLQET SEQLVALKP WITRQNFSR CLELQCQPD SSTLPPPWS PRPLEATAP TA
|Research Interest:||Stem Cell Research, Immunology, Cancer, Proliferation and Cell Cycle|
|Cell Type:||Stem Cells|
|Protein Cross Reactivity:||Monkey, Mouse, Rat|