Recombinant Human DKK-1
Catalog Number : 120-30
DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.
Above 97% as determined by SDS-PAGE Analysis.
Determined by its ability to inhibit mWnt3a-induced TCF/LEF-luciferase activity in reporter HEK293 cells.
TLNSVLNSN AIKNLPPPL GGAAGHPGS AVSAAPGIL YPGGNKYQT IDNYQPYPC AEDEECGTD EYCASPTRG GDAGVQICL ACRKRRKRC MRHAMCCPG NYCKNGICV SSDQNHFRG EIEETITES FGNDHSTLD GYSRRTTLS SKMYHTKGQ EGSVCLRSS DCASGLCCA RHFWSKICK PVLKEGQVC TKHRRKGSH GLEIFQRCY CGEGLSCRI QKDHHQASN SSRLHTCQR H
|Research Interest:||Cancer, Neurosciences, Bone Biology|
|Protein Cross Reactivity:||NULL|