Recombinant Human CYR61
Catalog Number : 120-25
CYR61 is a member of the CCN family of secreted cysteine rich regulatory proteins. CYR61 induces angiogenesis by stimulating the proliferation, migration, and adhesion of endothelial cells. Cell migration and adhesion are mediated through binding to specific cell surface integrins and to heparin sulfate proteoglycans. Increased expression of CYR61 is associated with several types of cancer, and correlates with the progression and estrogen independence of human breast cancers. Recombinant human CYR61 is a 39.5 kDa protein containing 357 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).
Above 95% as determined by SDS-PAGE Analysis.
Determined by the dose-dependent stimulation of the proliferation of murine 3T3 cells. The expected ED50 for this effect is 2.0-3.0 μg/ml.
MTCPAACHC PLEAPKCAP GVGLVRDGC GCCKVCAKQ LNEDCSKTQ PCDHTKGLE CNFGASSTA LKGICRAQS EGRPCEYNS RIYQNGESF QPNCKHQCT CIDGAVGCI PLCPQELSL PNLGCPNPR LVKVTGQCC EEWVCDEDS IKDPMEDQD GLLGKELGF DASEVELTR NNELIAVGK GSSLKRLPV FGMEPRILY NPLQGQKCI VQTTSWSQC SKTCGTGIS TRVTNDNPE CRLVKETRI CEVRPCGQP VYSSLKKGK KCSKTKKSP EPVRFTYAG CLSVKKYRP KYCGSCVDG RCCTPQLTR TVKMRFRCE DGETFSKNV MMIQSCKCN YNCPHANEA AFPFYRLFN DIHKFRD
|Research Interest:||Cancer, Angiogenesis, Proliferation and Cell Cycle|
|Protein Cross Reactivity:||Mouse|