Recombinant Human CTGFL/WISP-2
Catalog Number : 120-16
CTGFL/WISP-2 is a 28.6 kDa protein that belongs to the CCN family of cysteine rich regulatory proteins. Members of this family stimulate mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest, and migration of multiple cell types. The protein is expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart. In addition to promoting adhesion of osteoblasts, CTGFL/WISP-2 inhibits osteocalcin production, as well as binding of fibrinogen to integrin receptors. Recombinant human CTGFL/WISP-2 is a 24.3 kDa protein of 228 amino acid residues.
Above 95% as determined by SDS-PAGE Analysis.
The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is between 10-20 ng/ml in the presence of 15 ng/ml of human IGF-II.
MQLCPTPCT CPWPPPRCP LGVPLVLDG CGCCRVCAR RLGEPCDQL HVCDASQGL VCQPGAGPG GRGALCLLA EDDSSCEVN GRLYREGET FQPHCSIRC RCEDGGFTC VPLCSEDVR LPSWDCPHP RRVEVLGKC CPEWVCGQG GGLGTQPLP AQGPQFSGL VSSLPPGVP CPEWSTAWG PCSTTCGLG MATRVSNQN RFCRLETQR RLCLSRPCP PSRGRSPQN SAF
|Research Interest:||Apoptosis, Angiogenesis|
|Protein Cross Reactivity:||NULL|