Recombinant Human CTGF
Catalog Number : 120-19
CTGF is a member of the CCN family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by umbilical vein and vascular endothelial cells. CTGF stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial, and epithelial cells, and binds to IGF, TGF β1, and BMP-4. Cell migration and adhesion are signaled through binding to specific cell surface integrins and to heparin sulfate proteoglycans CTGF (98 a.a.), a lower molecular weight isoform containing the C-terminal portion of the full length CTGF protein, exerts full heparin binding, cell adhesion, and mitogenic CTGF activity. Recombinant human CTGF is a 11.0 kDa protein of 97 amino acid residues.
Above 95% as determined by SDS-PAGE Analysis.
Determined by the dose-dependent stimulation of the proliferation of HUVEC cells. The expected ED50 for this effect is 1.0-2.0 µg/ml.
GKKCIRTPK ISKPIKFEL SGCTSMKTY RAKFCGVCT DGRCCTPHR TTTLPVEFK CPDGEVMKK NMMFIKTCA CHYNCPGDN DIFESLYYR KMYGDMA
|Research Interest:||Stem Cell Research, Apoptosis, Cancer, Angiogenesis, Proliferation and Cell Cycle|
|Protein Cross Reactivity:||Mouse, Rat|