Recombinant Human Cardiotrophin-1
Catalog Number : 300-32
CT-1 is a member of the IL-6 family of cytokines which also includes LIF, CNTF, OSM (Oncostatin M), IL-11, IL-6 and possibly NNT-1/BSF-3. CT-1 is a pleiotropic cytokine which is expressed in various tissues including the adult heart, skeletal muscle, ovary, colon, prostate and fetal lung and signals through the LIF receptor and the gp130 receptor subunit. CT-1 has the ability to induce cardiac myocyte hypertrophy, and enhances the survival of cardiomyocyte and different neuronal populations. Biologically active human CT-1 is synthesized as a 201 amino acid polypeptide lacking a hydrophobic N-terminal secretion signal sequence. Recombinant Human CT-1 is a 21.1 kDa protein consisting of 200 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
SRREGSLED PQTDSSVSL LPHLEAKIR QTHSLAHLL TKYAEQLLQ EYVQLQGDP FGLPSFSPP RLPVAGLSA PAPSHAGLP VHERLRLDA AALAALPPL LDAVCRRQA ELNPRAPRL LRRLEDAAR QARALGAAV EALLAALGA ANRGPRAEP PAATASAAS ATGVFPAKV LGLRVCGLY REWLSRTEG DLGQLLPGG SA
|Research Interest:||Angiogenesis, Neurosciences, Bone Biology|
|Protein Cross Reactivity:||Rat|