Recombinant Human Betacellulin
Catalog Number : 100-50
Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.
Above 98% as determined by SDS-PAGE Analysis.
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 0.05 ng/ml, 7units/mg.
DGNSTRSPE TNGLLCGDP EENCAATTT QSKRKGHFS RCPKQYKHY CIKGRCRFV VAEQTPSCV CDEGYIGAR CERVDLFY
|Protein Cross Reactivity:||Mouse|