Recombinant Human Betacellulin
Catalog Number : 100-50
description
Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.
Additional Information
Source:
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E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity:
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Mouse
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Biological Activity
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The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 0.05 ng/ml, 7units/mg.
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AA Sequence
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DGNSTRSPE TNGLLCGDP EENCAATTT QSKRKGHFS RCPKQYKHY CIKGRCRFV VAEQTPSCV CDEGYIGAR CERVDLFY
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Application: | FA |
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Protein Cross Reactivity: | Mouse |