Recombinant Human BDNF

Grouped product items
Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$1,040.00
500µg
$3,120.00
1mg
$5,200.00
Catalog Number : 450-02

description

BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
Chicken, Frog, Guinea Pig, Hamster, Monkey, Mouse, Rat
Biological Activity
Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.
AA Sequence
MHSDPARRG ELSVCDSIS EWVTAADKK TAVDMSGGT VTVLEKVPV SKGQLKQYF YETKCNPMG YTKEGCRGI DKRHWNSQC RTTQSYVRA LTMDSKKRI GWRFIRIDT SCVCTLTIK RGR
Research Interest: Stem Cell Research, Neurosciences, Proliferation and Cell Cycle
Cell Type: Neurons
Application: FA
Protein Cross Reactivity: Chicken, Frog, Guinea Pig, Hamster, Monkey, Mouse, Rat
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