Recombinant Human BAFF
Catalog Number : 310-13
BAFF, a member of the TNF family of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. BAFF is involved in stimulation of B and T cell function, and is an important survival and maturation factor for peripheral B cells. BAFF signals through three different TNF receptors TACI, BCMA and BAFF-R. The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain. Recombinant human soluble BAFF is a 152 amino acid polypeptide (17.0 kDa), which contains the TNF-like portion of the extracellular domain of BAFF.
Above 95% as determined by SDS-PAGE Analysis.
Determined by a mouse splenocyte survival assay. The expected ED50 for this effect is 0.5-2.0 µg/ml.
AVQGPEETV TQDCLQLIA DSETPTIQK GSYTFVPWL LSFKRGSAL EEKENKILV KETGYFFIY GQVLYTDKT YAMGHLIQR KKVHVFGDE LSLVTLFRC IQNMPETLP NNSCYSAGI AKLEEGDEL QLAIPRENA QISLDGDVT FFGALKLL
|Research Interest:||Stem Cell Research, Apoptosis, Immunology|
|Cell Type:||B Cells, Macrophage / Monocyte, T Cells, Dendritic Cells|
|Protein Cross Reactivity:||Mouse|