Recombinant Human APRIL
Catalog Number : 310-10C
APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA. ARPIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor. Recombinant human APRIL is a soluble 16.3 kDa protein, consisting of 146 amino acid residues.
*Human APRIL(Catalog Number 310-10C) has replaced Human APRIL(Catalog Number 310-10)
Hi-5 Insect cells
Above 95% as determined by SDS-PAGE Analysis.
Measured by its ability to induce cell death in Jurkat cells.
AVLTQKQKK QHSVLHLVP INATSKDDS DVTEVMWQP ALRRGRGLQ AQGYGVRIQ DAGVYLLYS QVLFQDVTF TMGQVVSRE GQGRQETLF RCIRSMPSH PDRAYNSCY SAGVFHLHQ GDILSVIIP RARAKLNLS PHGTFLGFV KL
|Research Interest:||Adaptive Immunity, Apoptosis, Immunology, Cancer|
|Cell Type:||B Cells, Macrophage / Monocyte, T Cells|
|Protein Cross Reactivity:||NULL|