Recombinant Human Amphiregulin
Catalog Number : 100-55B
Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-a receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant human Amphiregulin is a 11.3 kDa glycoprotein consisting of 98 amino acid residues.
Above 95% as determined by SDS-PAGE Analysis.
Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/ml.
SVRVEQVVK PPQNKTESE NTSDKPKRK KKGGKNGKN RRNRKKKNP CNAEFQNFC IHGECKYIE HLEAVTCKC QQEYFGERC GEKSMKTHS MIDSSLSK
|Research Interest:||Cancer, Angiogenesis, Neurosciences, Bone Biology, Inflammation|
|Protein Cross Reactivity:||NULL|