Recombinant Human Vimentin

Grouped product items
SizePrice Qty
20µg
$80.00
100µg
$195.00
250µg
$385.00
500µg
$660.00
1mg
$1,100.00
Catalog Number : 110-10

description

Vimentin is a class III intermediate filament protein predominantly found in cells of mesenchymal origins, such as vascular endothelium and blood cells, where it functions as a major cytoskeletal component. Due to its importance and abundance in the cytoskeletal structure of mesenchymally-derived cells, Vimentin is frequently used as a developmental marker within cells of mesenchymal origin or cells undergoing epithelial-mesenchymal transition, which can occur during both normal and metastatic growth. An active participant within several critical processes of cellular organization and protein regulation, Vimentin is involved in the anchorage of organelles within the cytoplasmic matrix, development of astrocytes, and the disassembly of cellular components during the execution phase of apoptosis. Abnormalities in the normal physiological pathways of Vimentin have been implicated in deficient motility and directional migration involved in wound healing and cellular growth and development, as well as the adhesion-site accumulation of Vimentin on lens epithelial cells in cases of dominant cataracts. Recombinant Human Vimentin is a 54.5 kDa protein consisting of 472 amino acid residues, including a 6 residue C-terminal His-Tag.

Additional Information

Source:
E. Coli
Purity:
Above 95% as determined by SDS-PAGE Analysis.
Cross Reactivity:
NULL
Biological Activity
Data not available.
AA Sequence
MSTRSVSSS SYRRMFGGP GTASRPSSS RSYVTTSTR TYSLGSALR PSTSRSLYA SSPGGVYAT RSSAVRLRS SVPGVRLLQ DSVDFSLAD AINTEFKNT RTNEKVELQ ELNDRFANY IDKVRFLEQ QNKILLAEL EQLKGQGKS RLGDLYEEE MRELRRQVD QLTNDKARV EVERDNLAE DIMRLREKL QEEMLQREE AENTLQSFR QDVDNASLA RLDLERKVE SLQEEIAFL KKLHEEEIQ ELQAQIQEQ HVQIDVDVS KPDLTAALR DVRQQYESV AAKNLQEAE EWYKSKFAD LSEAANRNN DALRQAKQE STEYRRQVQ SLTCEVDAL KGTNESLER QMREMEENF AVEAANYQD TIGRLQDEI QNMKEEMAR HLREYQDLL NVKMALDIE IATYRKLLE GEESRISLP LPNFSSLNL RETNLDSLP LVDTHSKRT LLIKTVETR DGQVINETS QHHDDLEHH HHHH
Research Interest:Apoptosis, Proliferation and Cell Cycle
Application:FA
Protein Cross Reactivity:NULL
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